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High concentrations and prolonged exposure to ROS causes extensive damage to various integral cellular biomolecules (Figure 1B), including proteins, lipids and nucleic acids, which ultimately hampers multiple cellular functions (49, 88)

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However, as is the case with sublingual NAD+ boosters, evidence to support any specific dose is nonexistent

This will allow beta and gamma-secretase to cleave APP, increasing Amyloid Beta and plaque formation in the brain ( Levels of ADAM10 are reduced in mild cognitive impairment, indicating its role as an early indicator of cognitive impairment ( Figure 1 )

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