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Interestingly, the loop connecting helices 2 and 3 ( 208- GTSSTG 213 ) of SemDAPH is stabilised in the complex and can now be modelled

We have also considered the important role of copper, both as a catalyst and as an inducer of oxidative stress

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Additionally, nitrosamines (e.g., NDMA) generate alkylating intermediates that damage the genome through DNA adducts such as m6G, inducing abnormal DNA methylation and increasing the risk of malignant transformation in bladder cancer cells (Anderson et al., 1996