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Finally, we have also identified changes at the loci of Fibrillin-1 ( FBN1 ) 72 and Thrombospondin Type 1 Domain Containing 4 ( THSD4 , ADAMTSL-6 ) 73 , which encode ECM proteins that contribute to ECM structures regulating latent TGF- availability (Supplementary Fig

Advances in Experimental Medicine and Biology, vol 1063

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Structure calculation and all-atom MD simulations SERF2 backbone assignments were done using standard 3D experiments, including HNCA, HNCACB, CBCAcoNH and HNCO experiments, along with the 2D HSQC collected at 4 C

Therefore, keeping the dynamic balance of ROS plays an important role in maintaining NPCs stability