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The program established a favorable safety profile but the Phase IIb endpoint did not differentiate sufficiently from placebo to support continued development for obesity

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82 A subsequent study using transcriptomic and proteomic analyses identified that proNeu1, marked by Lin CD117 + CD34 hi Ly6C + CD115 CD81 + CD106 CD11b lo and present in GMP, initially generates the intermediate progeny proNeu2, marked by CD117 + CD34 lo Ly6C + CD115 CD81 + CD106 + CD11b hi , and then differentiates into Lin Siglec-F CD117 + CXCR4 + Gr1 + CD11b + preNeu

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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Choi B.-H., Coloff J.L