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Although modulating B-cell-driven inflammatory amplification may hold therapeutic value, current evidence is still insufficient to support B cells as a direct therapeutic target, especially given that most mechanistic data derive from murine models and their contribution to human disease remains uncertain

Key secreted molecules include pro-angiogenic cytokines (VEGF, HGF, FGF [Fibroblast Growth Factor], IGF-1 [Insulin-like Growth Factor 1], PDGF [Platelet-Derived Growth Factor]), neurotrophic factors (NGF [Nerve Growth Factor], BDNF [BrainDerived Neurotrophic Factor]), and anti-apoptotic/anti-fibrotic mediators (TSG-6 [TNF-stimulated gene 6 protein], IL-10) [83]

Endo et al., 2022

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Effects of bifidobacterium longum and lactobacillus rhamnosus on gut microbiota in patients with lactose intolerance and persisting functional gastrointestinal symptoms: a randomised, double-blind, cross-over study

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