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doi: 10.3390/ijms21010055 37 LinTYLanWHChiuYFFengCLChiuCHKuoCJet al

Esculetin improved lipid metabolism in FFA-treated primary hepatocytes by decreasing expression of Srebp1c and increasing expression of Ppar- as well as reducing lipid accumulation

Certain vitamins also serve as substrates in these epigenetic reactions (Meier 2013)

Treatment with an antagonist of the EP2 receptor (a downstream regulator of PTGS2) caused a significant reduction in the seizure frequency, incidence and duration of seizures, alluding to the role of PTGS2 46