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Interestingly, under iron-rich conditions and in the absence of host influences, iron has adverse effects, including a decrease in beneficial microorganisms and an increase in bacterial metabolite levels, which in turn impairs the barrier function of intestinal epithelial cells [73]

296 In addition, in the further study with tumor-bearing mice models, macrophages from mice of different ages exist diverse phenotypes, indicating that aging is accompanied with changes in inflammatory cells and will affect tumor progression

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