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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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Their capacity to raise butyrate and propionate levels has been linked to increased Nrf2 activation, decreased oxidative stress, and the stability of dopaminergic pathways

Food Chem 102(1):392398 Kallel L, Desseaux V, Hamdi M, Stocker P, Ajandouz EH (2012) Insights into the fermentation biochemistry of kombucha teas and potential impacts of kombucha drinking on starch digestion

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Gambogic acid induces GSDME dependent pyroptotic signaling pathway via ROS/P53/Mitochondria/Caspase-3 in ovarian cancer cells