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Based on available evidence, SCFAs exert protective effects by activating the Nrf2/GPX4 pathway to inhibit lipid peroxidation, while LPS acts through the dual mechanisms of suppressing the antioxidant defense system (GPX4) and disrupting iron metabolic homeostasis

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This clinical review assessed the role of IL-1R antagonist treatment with anakinra in patients with different forms of cytokine storm, providing critical evidence to support the use of this therapy

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BMI decreased on average 5.3% in the first 12 weeks, in the second twelve weeks the reduction in BMI reached on average was statistically significant see Figure 6