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The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/akt and NF-kappaB-inducing kinase pathways: Role of H(2)O(2) in NF-kappaB activation

We then pre-incubated early ring-stage artemisinin resistant and sensitive parasites with BSO for 1 h prior to pulse treatment with 700 nM of DHA for 6 h and measured survival, analogous to the standard in vitro Ring-stage Survival Assay (RSA) for artemisinin resistance

It is also noteworthy that metabolic dysfunction in CD8+ T cells, driven by the immunosuppressive microenvironment of chronic lymphocytic leukaemia (CLL), contributes to CAR-T therapy resistance (Van Bruggen et al, 2019)

For example, ROS produced by macrophages can induce the generation of Tregs [238], while mice lacking neutrophil cytosolic factor 1, even with low ROS levels, have more responsive Tregs than wild-type mice [168]

Wood retired as CEO of Wood Partners, LLC in November 2007

doi: 10.1038/nrd4002 260 PiskounovaEAgathocleousMMurphyMMHuZHuddlestunSEZhaoZet al