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Furthermore, T0901317, an LXR agonist, restored LXR signalling, cholesterol efflux, and improved inflammation as reflected by reduced levels of IL-6 (-25%), TNFA (-75%), and NFkB1 (-50%)

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Rotenone causes oxidative damage by inducing oxidative stress and depleting antioxidants such as superoxide dismutase (SOD), reduced glutathione (GSH) and catalase [105]

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Macroevolution of plant defense strategies

We constructed the WT-complemented H37Rv (Rv0884c_cKD Tet +Rv0884c) strain and a mutant-complemented H37Rv (Rv0884c_cKD Tet +Rv0884c (F108A)) strain, in which the catalytic activity is abrogated