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Chronic neuroinflammation can sustain oxidative stress and neuronal damage, creating a feedback loop that exacerbates disease progression [164]

Autophagy regulatory factors such as BECN1, human cathepsin B (CTSB), high mobility group protein B1 (HMGB1), phosphatidylethanolamine-binding protein 1 (PEBP1), mTOR, AMPK, and dual-specificity phosphatase 1 (DUSP1) also affect the ferroptosis process under certain conditions

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Consistent with this, silicon upregulates the expression of OsHMA3 in the root system ( Nramp5 , Nramp1 , HMA2 and HMA3 ) that encode cadmium transporter proteins in rice

Am J Gastroenterol (2018) 113:164959