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PLC (500 mg/kg b.w.) improved antioxidant defenses (increased GSH and decreased TBARS) in rat cardiac tissues and prevented the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model [100]

Moreover, in the ensuant subgroup analysis, the authors showed that l-carnitine supplementation had a significant and beneficial effect on ALT and AST, only at dosages 2 g/day, whilst treatment periods less than 12 weeks or more than 12 weeks were both meaningful [28]

Consult a health care practitioner for use beyond 8 weeks

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This is due to the fact that CaiT is an antiporter catalyzing exchange of intracellular and extracellular trimethylammonium compounds such as L-carnitine, crotonobetaine, and -butyrobetaine, while it does not catalyze uniport of L-carnitine out of the E

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