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The addition of silver (Ag), lithium (Li) or copper (Cu) in BG compositions brought new advantages, including soft tissue regeneration, wound healing, and antibacterial applications 7,10,11

Epitalons appeal lies in its unusually broad mechanistic reach: it can activate telomerase and support telomere maintenance in human cells [12,13,14, 15], modulate gene expression epigenetically by influencing chromatin accessibility and promoter interactions [4], enhance tissue repair in disease contexts such as diabetic retinopathy by reducing oxidative stress and EMT while improving wound healing in retinal cells [16], bolster redox homeostasis by upregulating endogenous antioxidant defenses and lowering DNA-damage markers [1], rebalance immune tone via IL-2 upregulation [17] and shifts in CD4+/CD8+ profiles [18], and even reset circadian biology by tuning core clock genes and melatonin dynamics [19, 20]

Invest Ophthalmol Vis Sci 2005

References Center for Drug Evaluation and Research

Cell 175 , 372386.e17 (2018)

This process involves starting with a lower dose and gradually increasing it over several weeks or months until the target therapeutic dose is reached