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However, they generally involve an initial cutaneous inflammation, which is followed by an altered wound healing response, which causes an imbalance in matrix degradation and collagen biosynthesis

Gut 69, 21312142

A production is influenced by cholesterol levels in neuronal membranes

PMID: 15854962

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Interestingly, the immunological phenomenon of original antigenic sin, where immune responses to subsequent similar but nonidentical antigens are dominated by less effective cross-reactive immunity rather than generating de novo highly specific and effective immunity, has been described for influenza