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3.1 DNA methylation and gene expression in CL In corpus luteum (CL) formation and functioning, epigenetic changes, and particularly DNA methylation are critical to gene expression regulation ( de novo methyltransferase ( Methylation of DNA normally occurs on CpG dinucleotides and is linked to transcriptional silencing ( The epigenetic control is also found in genes that are involved in the development of the vascular system such as vascular endothelial growth factor (VEGF), among others ( In luteal cells, DNA methylation dynamically regulates the transcription of steroidogenic genes

Furthermore, UCB retards OPC development, increasing the amount of immature (NG2 +) cells while decreasing OLGs (MBP +) [27]

Johann Matschke, [email protected] These authors have contributed equally to this work and share second authorship These authors have contributed equally to this work and share last authorship This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

A compound formulation of EGF-modified paclitaxel micelles and EGF-modified emodin micelles enhance the therapeutic effect of ovarian cancer