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Although the liver is also the principal source of circulating IGFBP-3 and ALS, other tissues have been proposed to produce these factors[48, 49]

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10.3233/jad-160763 J

Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of 1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve

Lang CA, et al