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10.1111/j.1471-4159.2004.02406.x J

HIF-1 is upregulated in PASMCs of chronic cobalt chloride-induced PAH rats, which phosphorylates Drp1 by increasing Cyclin B/CDK1, subsequently leading to increased expression of the PDHK2 and PDHK4 genes, resulting in increased lactate production and promotion of glycolysis