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Inclusion criteria selected for patients with a diagnosis of epilepsy, an average of at least 2 seizures per month over the preceding 3 months prior to starting MAD, at least 18 years of age at the time of enrollment, having baseline carnitine lab measurement prior to starting MAD, and at least one carnitine lab measurement at a follow-up timepoint

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The cells were then incubated with monoclonal anti-Nrf2 antibody (1:100, Santa Cruz sc-518033) at 4 C, over-night

These experiments indicate that the late ER stress-activated MGST2-LTC 4 pathway is one of the major routes leading to cell death, mediated by intracrine action of LTC 4 and involving oxidative stress, inflicted by LTC 4 -triggered activation of NOX4

Varela-Nieto, I., Harti, M., Gorospe, I