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Consistent with this mechanism of action, reduced levels of ATP-binding cassette (ABC) transporter A7 (ABCA7), which is encoded by the GWAS ABCA7 gene and mediates the efflux of cholesterol and phospholipids to form high-density lipoproteins, correspond to increased lipotoxicity ( SORL1 , another GWAS gene, encodes an apolipoprotein E receptor, which has also emerged from a combined lipidomic and proteomic study of Alzheimers disease (Xu et al., 2020)

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