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The result is structurally abnormal cardiolipin that cannot support ETC supercomplex integrity, causing severe mitochondrial cardiomyopathy, skeletal muscle weakness, and immunodeficiency

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11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Previous studies have shown enhanced conversion of inactive cortisone to active cortisol through the expression of 11-hydroxysteroid dehydrogenase type 1 (11HSD1) in cultured omental adipose stromal cells (218)