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Accordingly, inhibition of HIF-1 activity using KC7F2, able to downregulate HIF-1 protein synthesis and its transcriptional activity, or using a specific siHIF-1, resulted in the reversal of the promoting effects of 3T3-L1A-EVs on BC cell motility, invasion and metastasis (20)

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The cell type and state have a significant impact on the form, size, and number of these characteristics

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To further assess conformational dynamics, MD simulations were performed for nanobodies

doi: 10.1016/j.jaad.2008.10.012 73 BerginDAHurleyKMcElvaneyNGReevesEP