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Diagnosis is made by measuring the concentration of different metabolites in the gamma-glutamyl cycle, enzyme activity and in glutathione synthetase and gamma-glutamylcysteine synthetase deficiency, also by mutation analysis

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Electronic supplementary material The online version of this article (doi:10.1186/s12970-015-0067-x) contains supplementary material, which is available to authorized users

Compared to the negative control group, CCl 4 administration significantly raised blood AST, ALT, ALB, ALP, serum direct bilirubin, total bilirubin, and GGT

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Segal-Gavish et al., 2017) although the underlying mechanism of the effect of genetic mutation on cognitive function has not been delineated yet (Jouroukhin et al., 2019)