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First, the 2020 update on gout guidelines from the American College of Rheumatology now recommends initiating urate-lowering therapy (ULT) during gout flares

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Note that we could not use single worm transcriptomic analyses for this large set of conditions and instead, performed these experiments by harvesting cultures with preferentially adult individuals

4 The authors further noted that the septic process within the joint can lead to crystal shedding, so the presence of crystals does not rule out a septic joint