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the result is a haze, color shift, or visible precipitate within hours

Rather than slowing gastric emptying or mimicking incretin hormones, tesofensine directly modulates central nervous system neurochemistry to influence appetite, satiety signaling, and energy expenditure

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doi: 10.1080/10942919809524561

For example, the compound 13 (racemic) is a very week IRAP inhibitor (Lukaszuk et al., 2011) and compound 14 with a 4-hydroxydiphenylmethane scaffold as a substitute for Tyr 2 is essentially inactive (Figure 4) (Andersson et al., 2008)

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