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[1] [2] The American Diabetes Association (ADA) and the American College of Physicians (ACP) recommend metformin as the preferred initial pharmacologic agent for type 2 diabetes, alongside lifestyle modifications including diet and exercise

When used with insulin or sulfonylureas, it can cause low blood sugar levels

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Researchers studying the broader axis often combine IGF-1 LR3 work with separate studies using GH secretagogues like CJC-1295/Ipamorelin or Tesamorelin to drive endogenous GH and IGF-1 production, then compare results