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Biomarkers resulting from lipid peroxidation or GSH depletion (Table 2) can be generated and evaluated using conventional biochemical techniques, which are costly and require intricate purification procedures, advanced instrumentation, and substantial effort 46

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Supplementary Figure 1a-f ), which were enriched in multiple metabolic processes, among which amino acid metabolisms (e.g., glutamate metabolism, glycine and serine metabolism, and cysteine and methionine metabolism) being the most significantly downregulated pathways upon LDHB KD ( Figure 1b )

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