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Cancer Res 77(23):67466758 Akins NS, Nielson TC, Le HV (2018) Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer

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10.1001/jama.2023.19869 34 ErensoyH.NiafarM.GhafarzadehS.AghamohammadzadehN.NaderN

9,394,338 Applications Treatment for Alzheimers and other neurodegenerative diseases Key Benefits & Differentiators Increased stability: Resistance to -glutamyl transpeptidase (-GT) breakdown leads to extended antioxidant activity Replicates endogenous GSH activity: Crosses the blood-brain barrier and mimics key glutathione (GSH) functions Technology Overview Oxidative stress and plaque formation from glycation are key features of numerous neurodegenerative diseases, including Alzheimers disease

The current view is that the mechanism of heat injury is due to direct damage from heat and systemic inflammatory response syndrome (SIRS) caused by heat stress and endotoxin leakage

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