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the assumption is that a closely related sequence would engage similar machinery, but assumption is the operative word

Safety testing was done at concentrations like 0.05% in SPF products and 0.5% in a Human Repeated Insult Patch Test

Cell Death Discov 8(1):27

RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis

In one study, authors pointed out that PwPD presenting with Vit B12 deficiency have significant white matter lesions which are thought to be both of microvascular and demyelinating origins

Risk factors include exceeding recommended doses (often unintentionally due to acetaminophen being in many combination products), chronic heavy alcohol use, poor nutrition, and existing liver disease