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Although conjugated metabolites are usually less reactive, the active efflux of conjugated metabolites by the MRP transporters prevents their intracellular accumulation, thereby reducing the possibility of hydrolytic enzymes causing the regeneration of the active parent compound

Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain

JiMHQiuLLYangJJZhangHSunXRZhuSHet al

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation

AMPK controls various physiological functions, such as mitochondrial function, energy metabolism, insulin secretion, and biogenesis [171]

Methylfolate (5-MTHF) : Active Form : Methylfolate is the biologically active form of folate