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In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population

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69 HayashiK.MorishitaR.NakagamiH.YoshimuraS.HaraA.MatsumotoK.et al (2001)

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Results: Stroke is estimated to cost Europe 93 billion annually, with health and long-term care accounting for 49 billion (52%) of costs, equalling 2.2% of overall health expenditure in these 37 European countries