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It should be noted that the current research on gut microbiota and its metabolites in autoimmune diseases mainly focuses on basic research and animal experiments, and more clinical studies are needed to validate and clarify the roles in disease progression and treatment, so as to further understand the mechanism of the gut microbiota metabolites in ITP and to evaluate their potential clinical applications, which is particularly important for subsequent research

It is one potentially modifiable biochemical burden that may coexist with methylation imbalance, oxidative stress, copper-zinc dysregulation, pyroluria, gut dysfunction or immune activation