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Recently, our laboratory demonstrated that chronic CNS leptin infusion improved cardiac metabolism and function and attenuated progression of HF after MI induced by permanent ligation of the left descending coronary artery (Fig

Concerning metabolic effects, important data were reported by a recent meta-analysis which includes 17 non-duplicate RCTs with a total of 29,287 postmenopausal women, consisting of 15,350 (mean age ranged from 47 to 75 years) who were randomized to hormone replacement therapy including E alone (n = 5,553) or E + P (n = 9,797), and 13,937 randomized to placebo [356]

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PNAS 93 : 1229812303