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These bonds will be cleaved within the acidic environment in endosomes and lysosomes, which will expose the positively charged amino groups of the polymer backbone and trigger the influx of H + and Cl , resulting in the elevation of endosomal osmotic pressure and the inflow of H 2 O

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This finding may thus provide an explanation for the epidemiological observations that smoking or exposure to tobacco smoke increases the incidence of viral, bacterial, and mycobacterial diseases of the lung [138-141]

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Ongoing clinical trials and formulation development efforts aim to translate the preclinical promise of EGCG into effective clinical applications [4]

10.1210/jc.2014-1593 144 YangC.ZhaoN.LiD.ZouG.ChenY