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These products have not been evaluated by the MHRA or any regulatory authority for safety or efficacy in humans or animals

One proposed mechanism of action is that stimulation of 5-HT 2C receptors in pro-opiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus leads to increased release of -MSH (Garfield and Heisler, 2009)

The timing of compounds, escalation schedules, and cycle architecture all influence outcomes