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Multiple molecules are upregulated or downregulated with lactate metabolism changing through diverse pathways

It plays an important role in regulation of airway blood flow [37], smooth muscle contraction [172], immune cell/mast cell modulation [167, 169] and secretion output from submucosal glands [173, 174]

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Apr 2011;25(4):508-16

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Disease-associated mutations affect intracellular traffic and paracellular Mg 2+ transport function of claudin-16