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Sleep deprivation significantly impairs cognitive function

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However, despite the widespread nature of this condition, there are no internationally standardised guidelines regarding dosage regimes, optimal formulation, frequency of administration of B12 therapy and monitoring of therapeutic effect, leading to significantly variable international practice (Sobczyska-Malefora et al., 2021)

Persistent nausea, reflux, constipation, rising resting heart rate, or broken sleep shows that the current dose has not settled

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