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However, under risk factors such as hemodynamic changes, hypercholesterolemia, hypertension, diabetes, and smoking, endothelial cells transition from an anti-inflammatory and anticoagulant state to a pro-inflammatory and pro-thrombotic state

Dalbeth N, Pool B, Gamble GD, et al

2012, titled Curcumin and its Emerging Role in Pain Modulation and Pain Management, suggests curcumin modulates pain pathways similarly to some medications