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About 1 million cases of shingles occur in the US each year.3,4 ZOSTAVAX In clinical trials, the live-attenuated vaccine significantly reduced the incidence and severity of herpes zoster and PHN in adults 50 years old, but its effectiveness declines sharply with age (see Table 1), and its protection against shingles wanes to 4% within 8 years after inoculation in persons vaccinated at 60 years old.5-9 Zostavax is contraindicated for use in immunocompromised patients and it must be frozen during storage and transport

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