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Description

Z., Hu, K

By analyzing the cryo-EM structure, we noticed that the carbon ortho to the aldehyde (R2) is close to multiple residues, indicating the potential for substituents at this position (e.g., methyl, hydroxy, methoxy) to introduce a steric clash or sterically hinder the interaction between the C326 side chain and the aldehyde warhead

D.PrietoM.et al (2014)

Dermatological evidence indicates that melasma affects approximately 90% of the global female population at some point during their lifetime, with particularly high prevalence in skin phototypes III through VI