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A significant and recent development is the shift in research focus towards constructing models based on CRLs

That is two full months of dosing from one vial

In this case, it may be suitable to add 5% glucose, or another non-ionic solute which will balance the osmotic potential across the particle membrane when the particles are dialyzed to remove ethanol, increase the pH, or mixed with a pharmaceutically acceptable carrier such as normal saline

The mechanistic pathways described are largely inferred from preclinical models, in vitro experiments, and observational human studies

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doi: 10.1002/adhm.202202986 212 DengJZhuangHShaoSZengXXuePBaiTet al