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However, the chemical stability of ether bonds, which requires harsh conditions for cleavage, limits their metabolic degradation and may increase cytotoxicity risks [105]

The system was then returned to 100% Eluent A for 10 min, re-equilibrating the chromatographic column in preparation for the next injection

CrossRef 21,340 View 222 Download 45 Web of Science 58 Crossref Focused Review Series: Advanced Endoscopic Treatment for Pancreaticobiliary Diseases Endoscopic Ablation Therapy for Biliopancreatic Malignancies Jason Roque, Shiaw-Hooi Ho, Nageshwar Reddy, Khean-Lee Goh Clin Endosc 2015;48(1):15-19

doi: 10.1124/jpet.117.244376 104

(ii) modifiers of enzymes influencing methyl group availability

Future research should focus on further optimizing the formulation for large-scale production and exploring the detailed mechanisms underlying the observed pharmacodynamic effects