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Polyneuropathy typically presents gradually, beginning with paresthesia known as burning feet, followed by gait disturbances and variable muscle weakness in the lower limbs ( In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (42)

This shortage mainly results from the UK's reduced imports of selenium-rich North American wheat after joining the European Economic Community in 1973 [23]

The central idea is that modern life exposes us to far more environmental stressors than our systems were built for, and that accumulated burden interferes with normal function

doi:10.1371/journal.pone.0240584 Elia J, Wilson Z, La Porta LS, et al

doi: 10.1126/sciadv.abf7820 188 JiangYKrishnanNZhouJRChekuriSWeiXLKrollAVet al

Extended ATX supplementation, spanning a period of 8 months, led to a partial reversal of Erastin-induced alterations in human LECs from ARC models, which included the suppression of GPX4, an accumulation of ROS, and a decline in mitochondrial membrane potential (144)