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Neuroreport (1996) 7(18):30479

However, broader guidance from NICE, the NHS, and the MHRA provides a clear framework for understanding how unapproved substances should be approached

The results indicated a progressive increase in DCFH fluorescence intensity from 1 h to 24 h, indicating time-dependent accumulation

However, such changes exist only in localized regions affected by gliomas and result in a relatively low degree of increase in BBB permeability, which is inadequate for many therapeutic agents to enter the brain