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The anatomical proximity of the nasal mucosa to olfactory and trigeminal pathways makes the intranasal route relevant to pharmacokinetic and CNS penetration research in preclinical systems

Grouping: Sham group (physiological saline), OVX control group (physiological saline), AOD 9604 Capsule low-dose group (100 g/kg/day), AOD 9604 high-dose group (500 g/kg/day), positive drug group (teriparatide, 20 g/kg/day)

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However, it is prohibited by WADA for competitive athletes and is not approved for human consumption

Microorganisms such as Bacteroides vulgatus , Parabacteroides distasonis , Lactobacillus sali var ius , and various Clostridium species, have been reported to alter the neuroinflammatory signaling that impacts the functioning of the brain (61)