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Second, evaluating L-carnitine as a background therapy in combination with novel anti-fibrotic agents (e.g., GLP-1/GIP dual receptor agonists, FGF21 analogs) to assess its role in consolidating therapeutic efficacy and reducing relapse risk after drug discontinuation

People with metabolic diseases, such as metabolic syndrome, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (formerly NAFLD), [can also benefit from it] since ALCAR can support fatty acid metabolism, Warner adds

L-carnitine is available in several forms, including L-carnitine tartrate, acetyl-L-carnitine, and propionyl-L-carnitine, each with slightly different properties and effects

Moreover, significant changes in microbial communities combined with different dietary compositions may drive different molecular inputs to neuroendocrine signaling pathways, and these altered inputs (e.g., short-chain fatty acid response) combined with changes in the gut-brain axis may drive different systemic responses at the level of hormones and gene expression (49)

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