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PengJJSongWTYaoFZhangXPengJLuoXJet alInvolvement of regulated necrosis in blinding diseases: focus on necroptosis and ferroptosis

Crucially, it engages in direct molecular interactions and competition with FXR and PXR at shared gene regulatory elements, providing a clear mechanism for crosstalk between these major BA-sensing pathways

In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia (60)