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Excessive toxin intake or oxidative stress overload can lead to illness

A novel role of IGFBP7 in mouse uterus: regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization

Griffith RD, Simmons BJ, Yazdani Abyaneh MA, Bray FN, Falto-Aizpurua LA, Nouri K

Moreover, abnormal neuronal apoptosis is a prominent feature in neurodegenerative diseases such as AD, PD, amyotrophic lateral sclerosis, and Huntingtons disease, and is associated with multiple cellular processes such as oxidative stress, excitotoxicity, mitochondrial dysfunction, protein misfolding, and inflammation