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Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches

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In addition to RIDD, IRE1 also induces non-conventional splicing and activation of XBP1, a major transcription factor regulating ER homeostasis 10,66,67,68,69

This could occur by losing some components of the original cell membranes, such as glycosylation, or partially desaturate the membrane proteins, or again by displaying proteins with the right orientation on the NP surface

doi: 10.1016/j.redox.2022.102380 88 KNKakizakiYYanagidaKAraiTNakanoKHamanoFet al