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HIF-1 is widely expressed and is detected in virtually all innate and adaptive immune populations including macrophages (Cramer et al., 2003), neutrophils (Walmsley et al., 2005), dendritic cells (Jantsch et al., 2008), and lymphocytes (McNamee et al., 2013)

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A spokesperson for Genentech said the estimated monthly list price for the drug is around $2,900 for children and $5,000 for adults